We demonstrated that the improvement in RBC deformability and the decrease of RBC aggregates robustness in HU-treated patients limit the consequences of the increase of hemoglobin on blood viscosity.Ģ4 adult patients with SCA (38.3 ± 11.8 yrs, 61.9 ± 12.7 kg, 172.3 ± 10.9 cm 14 males/10 females) regularly followed by the Sickle Cell Center of Pointe-à-Pitre (Academic Hospital, Guadeloupe) and at steady-state, 2 were recruited consecutively. The aim of the present study was to test the effects of one year of HU therapy on blood rheology (RBC deformability and aggregation, blood viscosity), hematology and clinical profile in SCA adults. 5 4 However, no study has of yet investigated the effects of HU therapy on blood viscosity and RBC rheology. 3 1 Hydroxyurea (HU) therapy improves the clinical course of both children and adults with SCA. Abnormal blood rheology has been shown to modulate the clinical severity and to also be involved in several complications of SCA. The presence of sickle hemoglobin (HbS) in red blood cells (RBC) of patients with sickle cell anemia (SCA) is at the origin of their rheological abnormalities.
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